Multiple System Atrophy

GUIDELINES RELEVANT FOR MSA

  • n/a

CONSENSUS PAPERS

  • Second consensus statement on the diagnosis of multiple system atrophy. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Dürr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M. 2008 Aug 26;71(9):670-6. doi: 10.1212/01.wnl.0000324625.00404.15.
  • EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease. Berardelli A, Wenning GK, Antonini A, Berg D, Bloem BR, Bonifati V, Brooks D, Burn DJ, Colosimo C, Fanciulli A, Ferreira J, Gasser T, Grandas F, Kanovsky P, Kostic V, Kulisevsky J, Oertel W, Poewe W, Reese JP, Relja M, Ruzicka E, Schrag A, Seppi K, Taba P, Vidailhet M. Eur J Neurol. 2013 Jan;20(1):16-34. doi: 10.1111/ene.12022.
  • Proposedneuroimagingcriteria for the diagnosis of multiplesystematrophy. Brooks DJ, Seppi K. Neuroimaging Working Group on MSA. Mov Disord. 2009 May 15;24(7):949-64. doi: 10.1002/mds.22413.
  • Proposed neuropathological criteria for the post mortem diagnosis ofmultiple system  Trojanowski JQ, Revesz T. Neuropathology Working Group on MSA. Neuropathol Appl Neurobiol. 2007 Dec;33(6):615-20.
  • Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative. Laurens B, Constanstinescu R, Freeman R, Gerhard A, Jellinger K, Jeromin A, Krismer F, Mollenhauer M, Schlossmacher M,G, Shaw LM, Verbeek MM, Wenning GK, Winge K, Zhang J, Meissner WG. Neurobiol Dis. 2015 Aug;80:29-41. doi: 10.1016/j.nbd.2015.05.004. Epub 2015 May 15.

DIAGNOSTIC ALGORITHMS

  • Second consensus statement on the diagnosis of multiple system atrophy. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Dürr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M. 2008 Aug 26;71(9):670-6. doi:10.1212/01.wnl.0000324625.00404.15.

REGISTRIES

SCALES

  • Unified MSA Rating Scale (UMSARS): UMSARS is a rating scale for MSA comprising the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. It has been validated for MSA patients and appears to be a reliable scale for semiquantitative clinical assessments. Wenning GK, Tison F, Seppi K, et al. Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). Mov Disord. 2004 Dec;19(12):1391-402.
  • MSA Health-Related Quality of Life scale (MSA-QoL): The MSA-Qol is a disease-specific scale capturing diverse aspects affecting the quality of life of MSA patients. Measuring health-related quality of life in MSA: the MSA-QoL. Schrag A, Selai C, Mathias C, et al. Mov Disord. 2007 Dec;22(16):2332-8.
  • Composite Autonomic Symptom Scale (COMPASS and COMPASS-31)
  • Orthostatic Hypotension Questionnaire (OHQ)
  • Scales for Outcomes in Parkinson's Disease-Autonomic questionnaire (SCOPA-AUT)
  • Scale for the Assessment and Rating of Ataxia (SARA)
  • Berg Balance Scale (BBS)
  • PQoL Carers: Pillas M, Selai C, Quinn NP, Lees A, Litvan I, Lang A, Bower J, Burn D, Low P, Schrag A. Development and validation of a carers quality-of-life questionnaire for parkinsonism (PQoL Carers). Qual Life Res. 2016 Jan;25(1):81-8. doi: 10.1007/s11136-015-1071-y.

ADVOCACY AND SUPPORT GROUPS

RECENT REVIEW ARTICLES:

  • Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018;90(2):74-82.
  • Laurens B, Vergnet S, Lopez MC, Foubert-Samier A, Tison F, Fernagut PO, Meissner WG. Multiple System Atrophy - State of the Art. Curr Neurol Neurosci Rep. 2017;17(5):41.
  • Krismer F, Wenning GK. Multiple system atrophy: insights into a rare and debilitating movement disorder. Nat Rev Neurol. 2017;13(4):232-243.
  • Fanciulli A, Wenning GK. Multiple-system atrophy. N Engl J Med. 2015;372(14):1375-6. doi: 10.1056/NEJMc1501657.

Textversion ausgeblendet

Multiple System Atrophy resources

Guidelines relevant for MSA

  • n/a

Consensus papers

  • Second consensus statement on the diagnosis of multiple system atrophy. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Dürr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M. 2008 Aug 26;71(9):670-6. doi: 10.1212/01.wnl.0000324625.00404.15.
  • EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease. Berardelli A, Wenning GK, Antonini A, Berg D, Bloem BR, Bonifati V, Brooks D, Burn DJ, Colosimo C, Fanciulli A, Ferreira J, Gasser T, Grandas F, Kanovsky P, Kostic V, Kulisevsky J, Oertel W, Poewe W, Reese JP, Relja M, Ruzicka E, Schrag A, Seppi K, Taba P, Vidailhet M. Eur J Neurol. 2013 Jan;20(1):16-34. doi: 10.1111/ene.12022.
  • Proposedneuroimagingcriteria for the diagnosis of multiplesystematrophy. Brooks DJ, Seppi K. Neuroimaging Working Group on MSA. Mov Disord. 2009 May 15;24(7):949-64. doi: 10.1002/mds.22413.
  • Proposed neuropathological criteria for the post mortem diagnosis ofmultiple system  Trojanowski JQ, Revesz T. Neuropathology Working Group on MSA. Neuropathol Appl Neurobiol. 2007 Dec;33(6):615-20.
  • Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative. Laurens B1,Constantinescu R2Freeman R3Gerhard A4Jellinger K5Jeromin A6Krismer F7Mollenhauer B8Schlossmacher MG9Shaw LM10Verbeek MM11Wenning GK7Winge K12Zhang J13Meissner WG14. Neurobiol Dis. 2015 Aug;80:29-41. doi: 10.1016/j.nbd.2015.05.004. Epub 2015 May 15.
  • Consensus statements on the diagnosis and care of stridor and dysphagia are in preparation (consensus conference was held in Bologna, October 6 and 7, 2017)

Diagnostic algorithms

  • Second consensus statement on the diagnosis of multiple system atrophy. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Dürr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M. 2008 Aug 26;71(9):670-6. doi: 10.1212/01.wnl.0000324625.00404.15.

Registries

Scales

  • Unified MSA Rating Scale (UMSARS):
    UMSARS is a rating scale for MSA comprising the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. It has been validated for MSA patients and appears to be a reliable scale for semiquantitative clinical assessments. Wenning GK, Tison F, Seppi K, et al. Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). Mov Disord. 2004 Dec;19(12):1391-402.
  • MSA Health-Related Quality of Life scale (MSA-QoL):
    The MSA-Qol is a disease-specific scale capturing diverse aspects affecting the quality of life of MSA patients. Measuring health-related quality of life in MSA: the MSA-QoL. Schrag A, Selai C, Mathias C, et al. Mov Disord. 2007 Dec;22(16):2332-8.
  • Composite Autonomic Symptom Scale (COMPASS and COMPASS-31)
  • Orthostatic Hypotension Questionnaire (OHQ)
  • Scales for Outcomes in Parkinson's Disease-Autonomic questionnaire (SCOPA-AUT)
  • Scale for the Assessment and Rating of Ataxia (SARA)
  • Berg Balance Scale (BBS)
  • PQoL Carers

 Networks and study groups

Advocacy and support groups

Recent review articles: