Atypical Parkinsonian Syndromes and Genetic Parkinson’s Disease

This Disease Knowledge page provides reference information on care of atypical parkinsonism: Multiple System Atrophy and Progressive Supranuclear Palsy.

Disease Knowledge Documents

Information and knowledge that has been developed or endorsed by ERN-RND can be found in blue boxes.

Defintion

ERN-RND Centres for Atypical and Genetic PD

Centres and contact details for MSA, PSP, Genetic Parkinson’s Disease

Care Standards

Available in many European languages.

Diagnosis

Diagnostic Flowchart for Atypical Parkinsonism and Genetic PD (update 03/2026)

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Diagnosis of Atypical Parkinsonism for General Neurologists / General Practitioners

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Clinical Rating Scales

MDS-UPDRS: Clinical rating scales for Genetic Parkinson’s Disease (Updated 2024)

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UMSARS: Clinical rating scales for Multiple System Atrophy (Updated 2024)

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PSPRS: Clinical rating scales for Progressive Supranuclear Palsy (Updated 2024)

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Guidelines

NEUROGED Guidelines:
EAN x EFAS x INUS Guidelines on the assessment and treatment of neurogenic urinary and sexual symptoms

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Neurorehabilitation

ParkinsonNet Guideline

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Online Medical Education

Genetic Parkinson’s Disease

Genetic forms of parkinson’s disease by Thomas Gasser
The spectrum of genetic synucleinopathies by Leonidas Stefanis

Progressive supranuclear palsy

Progressive supranuclear palsy – update on diagnostics, biomarkers and therapies by Günter Höglinger

Cross-cutting thematic areas

Autonomic dysfunction in movement disorders by Pietro Guaraldi
Neurogeriatric and Neurological Aspects in Palliative Care by Martin Klietz
Autoimmune Parkisonism by Jeroen Kerstens
Recognizing atypical parkinsonism by Wassilios Meissner
Respiratory physiotherapy in parkinson’s plus syndromes by Jorik Nonnekes & Martin Srp
Patient Journeys: Reliable Comprehensive Documents which Summarise a Rare Disease by Petya Mihaylova & Mary Kearney
The Importance of Genetic Counselling in the Diagnostic of Rare Neurological Disorders by Maria Judit Molnar
Spring School 2026 – ‘RNAseq in RD’ by Diana Baralle
Spring School 2026 – ‘Episignatures in Diagnostics of Rare Diseases’ by Camille Charbonnier
Spring School 2026 – ‘Bioinformatic Tools for Diagnosing Rare Diseases’ by Christian Gilissen
Spring School 2026 – ‘Non-coding Variants in Rare Diseases’ by Nicola Whiffin
Spring School 2026 – ‘snRNA Genes in Neurodevelopmental Disorders’ by Christel Depienne
Spring School 2026 – ‘Recommendations’ by Katja Lohmann and Ales Maver
Spring School 2026 – ‘External Quality Assessment Scheme’ by Katja Lohmann and Ales Maver
Spring School 2026 – ‘Quality Insurance’ by Katja Lohmann and Ales Maver
Spring School 2026 – ‘NGS for Atypical Parkinsonian Syndromes’ by Georgios Koutsis

Patient Journeys

Available in many European languages .

Patient Journey for Multiple System Atrophy

Patient Journey Multiple System Atrophy

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Flyer Patient Journey Multiple System Atrophy

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Information for Patients – Endorsed by ERN-RND

Available in many European languages .

Leaflets

Information for Patients

Please note that this section includes useful information from a variety of sources provided by ERN-RND members but which hasn’t been endorsed by ERN-RND.